ACC.25 – In the phase 3 REVERSE-IT trial, the investigational monoclonal antibody bentracimab effectively and safely reversed the antiplatelet effect of ticagrelor in patients undergoing urgent surgery or with major bleeding.
Ticagrelor antidote restores platelet function in phase 3 study
ACC.25 – In the phase 3 REVERSE-IT trial, the investigational monoclonal antibody bentracimab effectively and safely reversed the antiplatelet effect of ticagrelor in patients undergoing urgent surgery or with major bleeding.

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Overview
Educational information
This video was recorded during the ACC.25 Scientific Session Chicago, IL, USA.
Faculty
Deepak Bhatt, MD is Director of Mount Sinai Heart, New York, NY, USA. He also is Dr. Valentin Fuster Professor of Cardiovascular Medicine at the Icahn School of Medicine at Mount Sinai in New York, NY, USA.
Disclaimer
This recording was developed under auspices of PACE-CME. Views expressed in the recording are those of the presenter and do not necessarily reflect the views of PACE-CME.
Release date: 1 April 2025
The information and data provided in this program were updated and correct at the time of its development, but may be subject to change.
Overview
ACC.25 – In the phase 3 REVERSE-IT trial, the investigational monoclonal antibody bentracimab effectively and safely reversed the antiplatelet effect of ticagrelor in patients undergoing urgent surgery or with major bleeding.
Educational information
This video was recorded during the ACC.25 Scientific Session Chicago, IL, USA.
Faculty
Deepak Bhatt, MD is Director of Mount Sinai Heart, New York, NY, USA. He also is Dr. Valentin Fuster Professor of Cardiovascular Medicine at the Icahn School of Medicine at Mount Sinai in New York, NY, USA.
Disclaimer
This recording was developed under auspices of PACE-CME. Views expressed in the recording are those of the presenter and do not necessarily reflect the views of PACE-CME.
Release date: 1 April 2025
The information and data provided in this program were updated and correct at the time of its development, but may be subject to change.
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